Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice

Many signaling pathways that contribute to tumorigenesis are also functional in pregnancy, although they are dysregulated in the former and tightly regulated in the latter. Transformation-related protein 53 (Trp53), which encodes p53, is a tumor suppressor gene whose mutation is strongly associated...

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Bibliographic Details
Main Authors: Hirota, Yasushi, Daikoku, Takiko, Tranguch, Susanne, Xie, Huirong, Bradshaw, Heather B., Dey, Sudhansu K.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827950/
https://ncbi.nlm.nih.gov/pubmed/20124728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40051
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