Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune loss of β cells, and neurological dysfunctions. We have previously shown that mutations in the Wolfram syndrome 1 (WFS1) gene cause Wolfram syndrome and that WFS1 has a p...

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Autori principali: Fonseca, Sonya G., Ishigaki, Shinsuke, Oslowski, Christine M., Lu, Simin, Lipson, Kathryn L., Ghosh, Rajarshi, Hayashi, Emiko, Ishihara, Hisamitsu, Oka, Yoshitomo, Permutt, M. Alan, Urano, Fumihiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827948/
https://ncbi.nlm.nih.gov/pubmed/20160352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39678
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