Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.

The beta 1- and beta 2-adrenergic receptors are two structurally related, but pharmacologically distinguishable, receptor subtypes, both of which activate adenylyl cyclase in a catecholamine-dependent manner through the guanine nucleotide-binding regulatory protein Gs. The receptors are approximatel...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Frielle, T, Daniel, K W, Caron, M G, Lefkowitz, R J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282779/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2849109/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.24.9494
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