DIMORPHIC MOTIFS IN D0 AND D1+D2 DOMAINS OF KIR3DL1 COMBINE TO FORM RECEPTORS WITH HIGH, MODERATE AND NO AVIDITY FOR THE COMPLEX OF A PEPTIDE DERIVED FROM HUMAN IMMUNODEFICIENCY VIRUS AND HLA-A*2402

Comparison of mutant KIR3DL1*015 substituted at natural positions of variation showed that tryptophan/leucine dimorphism at position 283 uniquely changes receptor conformation and can strongly influence binding of the A24nef tetramer. Dimorphic motifs at positions 2, 47 and 54 in D0 and 182 and 283...

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Main Authors: Sharma, Deepti, Bastard, Karine, Guethlein, Lisbeth A., Norman, Paul J., Yawata, Nobuyo, Yawata, Makoto, Pando, Marcelo, Thananchai, Hathairat, Dong, Tao, Rowland-Jones, Sarah, Brodsky, Frances M., Parham, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827337/
https://ncbi.nlm.nih.gov/pubmed/19752231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901734
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