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A means to an end: ubiquitination of Mpl
In this issue of Blood, Saur and colleagues report that ubiquitin-mediated degradation of the Mpl receptor constrains Tpo-mediated cell proliferation, highlighting the importance of the E3 ubiquitin ligase c-Cbl in rapid down-regulation of Tpo/Mpl signaling.
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2826227/ https://ncbi.nlm.nih.gov/pubmed/20150419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-252569 |
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