Biochemical and Structural Characterization of Cathepsin L-Processed Ebola Virus Glycoprotein: Implications for Viral Entry and Immunogenicity

Ebola virus (EBOV) cellular attachment and entry is initiated by the envelope glycoprotein (GP) on the virion surface. Entry of this virus is pH dependent and associated with the cleavage of GP by proteases, including cathepsin L (CatL) and/or CatB, in the endosome or cell membrane. Here, we charact...

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Bibliografiske detaljer
Main Authors: Hood, Chantelle L., Abraham, Jonathan, Boyington, Jeffrey C., Leung, Kwanyee, Kwong, Peter D., Nabel, Gary J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826059/
https://ncbi.nlm.nih.gov/pubmed/20053739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02151-09
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