A Single Amino Acid Substitution in the Capsid of Foot-and-Mouth Disease Virus Can Increase Acid Lability and Confer Resistance to Acid-Dependent Uncoating Inhibition

The acid-dependent disassembly of foot-and-mouth disease virus (FMDV) is required for viral RNA release from endosomes to initiate replication. Although the FMDV capsid disassembles at acid pH, mutants escaping inhibition by NH(4)Cl of endosomal acidification were found to constitute about 10% of th...

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Hlavní autoři: Martín-Acebes, Miguel A., Rincón, Verónica, Armas-Portela, Rosario, Mateu, Mauricio G., Sobrino, Francisco
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826036/
https://ncbi.nlm.nih.gov/pubmed/20053737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02311-09
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