The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes

BACKGROUND AND PURPOSE: Okadaic acid (OA) and microcystins (MCs) are structurally different toxins with the same mechanism of action, inhibition of serine/threonine protein phosphatases (PPs). Methyl okadaate (MeOk), a methyl ester derivative of OA, was considered almost inactive due to its weak inh...

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Autors principals: Espiña, Begoña, Louzao, MCarmen, Cagide, Eva, Alfonso, Amparo, Vieytes, Mercedes R, Yasumoto, Takeshi, Botana, Luis M
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2010
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825355/
https://ncbi.nlm.nih.gov/pubmed/20015092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00512.x
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