Mechanistic Issues of the Interaction of the Hairpin-Forming Domain of tBid with Mitochondrial Cardiolipin

BACKGROUND: The pro-apoptotic effector Bid induces mitochondrial apoptosis in synergy with Bax and Bak. In response to death receptors activation, Bid is cleaved by caspase-8 into its active form, tBid (truncated Bid), which then translocates to the mitochondria to trigger cytochrome c release and s...

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Bibliographic Details
Main Authors: Gonzalvez, François, Pariselli, Fabrizio, Jalmar, Olivier, Dupaigne, Pauline, Sureau, Franck, Dellinger, Marc, Hendrickson, Eric A., Bernard, Sophie, Petit, Patrice X.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825271/
https://ncbi.nlm.nih.gov/pubmed/20179769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009342
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