PI3Kγ Protects from Myocardial Ischemia and Reperfusion Injury through a Kinase-Independent Pathway

BACKGROUND: PI3Kγ functions in the immune compartment to promote inflammation in response to G-protein-coupled receptor (GPCR) agonists and PI3Kγ also acts within the heart itself both as a negative regulator of cardiac contractility and as a pro-survival factor. Thus, PI3Kγ has the potential to bot...

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Main Authors: Haubner, Bernhard J., Neely, G. Gregory, Voelkl, Jakob G. J., Damilano, Federico, Kuba, Keiji, Imai, Yumiko, Komnenovic, Vukoslav, Mayr, Agnes, Pachinger, Otmar, Hirsch, Emilio, Penninger, Josef M., Metzler, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825255/
https://ncbi.nlm.nih.gov/pubmed/20179753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009350
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