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Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
Vav proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases. They control processes including T cell activation, phagocytosis and migration of normal and transformed cells. We report the structure and biophysical and cellular analyses of the five-domain autoinhibitory element...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825156/ https://ncbi.nlm.nih.gov/pubmed/20141838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.12.033 |
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