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TRPM7 Activates m-Calpain by Stress-Dependent Stimulation of p38 MAPK and c-Jun N-Terminal Kinase

TRPM7 is a Ca(2+) and Mg(2+) permeant ion channel in possession of its own kinase domain. In a previous study we showed that overexpression of the channel-kinase in HEK-293 cells produced cell rounding and loss of adhesion which was dependent upon the Ca(2+)-dependent protease m-calpain. The TRPM7-e...

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Dettagli Bibliografici
Autori principali: Su, Li-Ting, Chen, Hsiang-Chin, González-Pagán, Omayra, Overton, Jeffrey D., Xie, Jia, Yue, Lixia, Runnels, Loren W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825087/
https://ncbi.nlm.nih.gov/pubmed/20070945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.014
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