An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen, Candida albicans

Candida albicans is an opportunistic fungal pathogen causing life-threatening mucosal and systemic infections in immunocompromised humans. Using a murine model of mucosal Candida infection we investigated the role of the proinflammatory cytokine IL-1β in host-defense to Candida albicans. We find tha...

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Bibliographic Details
Main Authors: Hise, Amy G., Tomalka, Jeffrey, Ganesan, Sandhya, Patel, Krupen, Hall, Brian A., Brown, Gordon D., Fitzgerald, Katherine A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824856/
https://ncbi.nlm.nih.gov/pubmed/19454352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2009.05.002
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