Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74

The receptor for calcitonin gene-related peptide (CGRP) has been the target for the development of novel small molecule antagonists for the treatment of migraine. Two such antagonists, BIBN4096BS and MK-0974, have shown great promise in clinical trials and hence a deeper understanding of the mechani...

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Hlavní autoři: Miller, Philip S., Barwell, James, Poyner, David R., Wigglesworth, Mark J., Garland, Stephen L., Donnelly, Dan
Médium: Artigo
Jazyk:Inglês
Vydáno: Academic Press 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824848/
https://ncbi.nlm.nih.gov/pubmed/19914210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.11.076
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