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A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes.

Using synthetic hepatitis B virus (HBV) mRNAs, we have shown that expression of HBV core-antigen gene sequences in Xenopus oocytes leads to the stable accumulation of 21-kDa cytoplasmic core protein (P21). In contrast, expression of precore plus core sequences leads mainly to the secretion of a hete...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Standring, D N, Ou, J H, Masiarz, F R, Rutter, W J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282466/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3186731/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.22.8405
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