The CDK4-pRB-E2F1 pathway controls insulin secretion

CDK4-pRB-E2F1 cell cycle regulators are robustly expressed in non-proliferating β-cells, suggesting that besides the control of β-cell number the CDK4-pRB-E2F1 pathway has a role in β-cell function. We show here that E2F1 directly regulates the expression of Kir6.2, which is a key component of the K...

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Hauptverfasser: Annicotte, Jean-Sébastien, Blanchet, Emilie, Chavey, Carine, Iankova, Irena, Costes, Safia, Assou, Said, Teyssier, Jacques, Dalle, Stéphane, Sardet, Claude, Fajas, Lluis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Macmillan Magazines Ltd. 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824657/
https://ncbi.nlm.nih.gov/pubmed/19597485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1915
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