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The CDK4-pRB-E2F1 pathway controls insulin secretion
CDK4-pRB-E2F1 cell cycle regulators are robustly expressed in non-proliferating β-cells, suggesting that besides the control of β-cell number the CDK4-pRB-E2F1 pathway has a role in β-cell function. We show here that E2F1 directly regulates the expression of Kir6.2, which is a key component of the K...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Macmillan Magazines Ltd.
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824657/ https://ncbi.nlm.nih.gov/pubmed/19597485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1915 |
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