Enhanced Interferon-γ Gene Expression in T Cells and Reduced Ovalbumin-Dependent Lung Eosinophilia in Hypoxia-Inducible Factor-1-α-Deficient Mice

BACKGROUND: There is growing evidence that hypoxia-inducible transcription factors are involved in the pathophysiology of asthma. Hypoxia-inducible factor-1α (HIF-1α) in particular controls the expression of many hypoxia regulated genes, but whether HIF-1α directly contributes to allergen-driven imm...

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Main Authors: Guo, Jia, Lu, Wenju, Shimoda, Larissa A., Semenza, Gregg L., Georas, Steve N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: S. Karger AG 2009
Ábhair:
Short Communication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824623/
https://ncbi.nlm.nih.gov/pubmed/19127065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000189191
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