Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

Vascular endothelial growth factor (VEGF) and β-catenin both act broadly in embryogenesis and adulthood, including in the skeletal and vascular systems. Increased or deregulated activity of these molecules has been linked to cancer and bone-related pathologies. By using novel mouse models to locally...

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Autori principali: Maes, Christa, Goossens, Steven, Bartunkova, Sonia, Drogat, Benjamin, Coenegrachts, Lieve, Stockmans, Ingrid, Moermans, Karen, Nyabi, Omar, Haigh, Katharina, Naessens, Michael, Haenebalcke, Lieven, Tuckermann, Jan P, Tjwa, Marc, Carmeliet, Peter, Mandic, Vice, David, Jean-Pierre, Behrens, Axel, Nagy, Andras, Carmeliet, Geert, Haigh, Jody J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824461/
https://ncbi.nlm.nih.gov/pubmed/20010698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.361
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