microRNA activity is suppressed in mouse oocytes

MicroRNAs (miRNAs) are small endogenous RNAs, which typically imperfectly base-pair with 3′UTRs and mediate translational repression and mRNA degradation. Dicer, an RNase III generating small RNAs in the miRNA and RNAi pathways, is essential for meiotic maturation of mouse oocytes. We found that 3′U...

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Bibliographic Details
Main Authors: Ma, Jun, Flemr, Matyas, Stein, Paula, Berninger, Philipp, Malik, Radek, Zavolan, Mihaela, Svoboda, Petr, Schultz, Richard M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824427/
https://ncbi.nlm.nih.gov/pubmed/20116252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.12.042
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