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microRNA activity is suppressed in mouse oocytes

MicroRNAs (miRNAs) are small endogenous RNAs, which typically imperfectly base-pair with 3′UTRs and mediate translational repression and mRNA degradation. Dicer, an RNase III generating small RNAs in the miRNA and RNAi pathways, is essential for meiotic maturation of mouse oocytes. We found that 3′U...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ma, Jun, Flemr, Matyas, Stein, Paula, Berninger, Philipp, Malik, Radek, Zavolan, Mihaela, Svoboda, Petr, Schultz, Richard M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824427/
https://ncbi.nlm.nih.gov/pubmed/20116252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.12.042
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