microRNA activity is suppressed in mouse oocytes

MicroRNAs (miRNAs) are small endogenous RNAs, which typically imperfectly base-pair with 3′UTRs and mediate translational repression and mRNA degradation. Dicer, an RNase III generating small RNAs in the miRNA and RNAi pathways, is essential for meiotic maturation of mouse oocytes. We found that 3′U...

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Bibliografiske detaljer
Main Authors: Ma, Jun, Flemr, Matyas, Stein, Paula, Berninger, Philipp, Malik, Radek, Zavolan, Mihaela, Svoboda, Petr, Schultz, Richard M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824427/
https://ncbi.nlm.nih.gov/pubmed/20116252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.12.042
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