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Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain

Membrane binding of Gag, a crucial step in HIV-1 assembly, is facilitated by bipartite signals within the matrix (MA) domain: N-terminal myristoyl moiety and the highly basic region (HBR). We and others have shown that Gag interacts with a plasma-membrane-specific acidic phospholipid, phosphatidylin...

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Hlavní autoři: Chukkapalli, Vineela, Oh, Seung J., Ono, Akira
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824378/
https://ncbi.nlm.nih.gov/pubmed/20080620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908661107
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