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Evidence in Support of RNA-Mediated Inhibition of Phosphatidylserine-Dependent HIV-1 Gag Membrane Binding in Cells

The matrix domain promotes plasma-membrane-specific binding of HIV-1 Gag through interaction with an acidic lipid phosphatidylinositol-(4,5)-bisphosphate. In in vitro systems, matrix-bound RNA suppresses Gag interactions with phosphatidylserine, an acidic lipid prevalent in various cytoplasmic membr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chukkapalli, Vineela, Inlora, Jingga, Todd, Gabrielle C., Ono, Akira
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676091/
https://ncbi.nlm.nih.gov/pubmed/23552424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00075-13
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