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Mechanistic details of a protein–protein association pathway revealed by paramagnetic relaxation enhancement titration measurements

Protein–protein association generally proceeds via the intermediary of a transient, lowly populated, encounter complex ensemble. The mechanism whereby the interacting molecules in this ensemble locate their final stereospecific structure is poorly understood. Further, a fundamental question is wheth...

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Autors principals: Fawzi, Nicolas L., Doucleff, Michaeleen, Suh, Jeong-Yong, Clore, G. Marius
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824347/
https://ncbi.nlm.nih.gov/pubmed/20080627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909370107
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