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Detecting and understanding combinatorial mutation patterns responsible for HIV drug resistance
We propose a systematic approach for a better understanding of how HIV viruses employ various combinations of mutations to resist drug treatments, which is critical to developing new drugs and optimizing the use of existing drugs. By probabilistically modeling mutations in the HIV-1 protease or reve...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824344/ https://ncbi.nlm.nih.gov/pubmed/20080674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907304107 |
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