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Rate, molecular spectrum, and consequences of human mutation
Although mutation provides the fuel for phenotypic evolution, it also imposes a substantial burden on fitness through the production of predominantly deleterious alleles, a matter of concern from a human-health perspective. Here, recently established databases on de novo mutations for monogenic diso...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824313/ https://ncbi.nlm.nih.gov/pubmed/20080596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912629107 |
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