Regulation of Cocaine Self-Administration in Humans: Lack of Evidence for Loading and Maintenance Phases

BACKGROUND: In rodents, cocaine self-administration under a fixed-ratio schedule and with timeout intervals limited to the duration of the infusions is characterized by an initial burst of drug intake (loading) followed by more stable infusion rates (maintenance). We sought to examine whether simila...

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Main Authors: Angarita, Gustavo A., Pittman, Brian, Gueorguieva, Ralitza, Kalayasiri, Rasmon, Lynch, Wendy J., Sughondhabirom, Atapol, Morgan, Peter T., Malison, Robert T.
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824073/
https://ncbi.nlm.nih.gov/pubmed/20005893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2009.12.005
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