Regulation of Cocaine Self-Administration in Humans: Lack of Evidence for Loading and Maintenance Phases

BACKGROUND: In rodents, cocaine self-administration under a fixed-ratio schedule and with timeout intervals limited to the duration of the infusions is characterized by an initial burst of drug intake (loading) followed by more stable infusion rates (maintenance). We sought to examine whether simila...

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Hlavní autoři: Angarita, Gustavo A., Pittman, Brian, Gueorguieva, Ralitza, Kalayasiri, Rasmon, Lynch, Wendy J., Sughondhabirom, Atapol, Morgan, Peter T., Malison, Robert T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824073/
https://ncbi.nlm.nih.gov/pubmed/20005893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2009.12.005
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