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Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension
Human NHA2 is a poorly characterized Na(+)/H(+) antiporter recently implicated in essential hypertension. We used a range of computational tools and evolutionary conservation analysis to build and validate a three-dimensional model of NHA2 based on the crystal structure of a distantly related bacter...
Sparad:
| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824056/ https://ncbi.nlm.nih.gov/pubmed/20053353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.12.055 |
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