Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons

We tested whether rosuvastatin (RST) protected against excitotoxic neuronal cell death in rat primary cortical neuronal cultures. L-glutamate (200µM, 1h) reduced neuronal viability (% of naive controls, mean±SEM, n=8–32, *p<0.05) from 100±2% to 60±1%*, but pretreatment with RST (0.5 µM, 3 days) i...

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Huvudupphovsmän: Domoki, Ferenc, Kis, Béla, Gáspár, Tamás, Snipes, James A., Bari, Ferenc, Busija, David W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824032/
https://ncbi.nlm.nih.gov/pubmed/19931334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2009.11.013
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