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Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons
We tested whether rosuvastatin (RST) protected against excitotoxic neuronal cell death in rat primary cortical neuronal cultures. L-glutamate (200µM, 1h) reduced neuronal viability (% of naive controls, mean±SEM, n=8–32, *p<0.05) from 100±2% to 60±1%*, but pretreatment with RST (0.5 µM, 3 days) i...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824032/ https://ncbi.nlm.nih.gov/pubmed/19931334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2009.11.013 |
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