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Hypoxia and the expression of HIF-1α and HIF-2α in the retina of streptozotocin-injected mice and rats

Decreases in retinal blood flow in diabetics could render the retina hypoxic. In mouse and rat models of diabetes, a decrease in retinal blood flow occurs early, within 3–4 weeks of the induction of hyperglycemia, although information is scarce on whether this early decrease in flow induces hypoxia....

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Main Authors: Wright, William S., McElhatten, Robert M., Messina, Jodine E., Harris, Norman R.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824016/
https://ncbi.nlm.nih.gov/pubmed/20005221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2009.12.002
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