Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms

Ethyl pyruvate (EP) is protective in experimental models of many illnesses. This study investigates whether EP can protect against neonatal hypoxic-ischemic (H-I) brain injury. Pre-treatment with EP significantly reduced brain damage at 7 days post-H-I, with 50 mg/kg EP achieving over 50% recovery i...

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Bibliografiske detaljer
Main Authors:	Shen, Hongxia, Hu, Xiaoming, Liu, Can, Wang, Suping, Zhang, Wenting, Gao, Hui, Stetler, R. Anne, Gao, Yanqin, Chen, Jun
Format:	Artigo
Sprog:	Inglês
Udgivet:	2009
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2824008/ https://ncbi.nlm.nih.gov/pubmed/20026271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.12.010
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Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms

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