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Inhibitory role for GABA in autoimmune inflammation

GABA, the principal inhibitory neurotransmitter in the adult brain, has a parallel inhibitory role in the immune system. We demonstrate that immune cells synthesize GABA and have the machinery for GABA catabolism. Antigen-presenting cells (APCs) express functional GABA receptors and respond electrop...

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Autors principals: Bhat, Roopa, Axtell, Robert, Mitra, Ananya, Miranda, Melissa, Lock, Christopher, Tsien, Richard W., Steinman, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823917/
https://ncbi.nlm.nih.gov/pubmed/20133656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0915139107
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