A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report th...

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Bibliografiske detaljer
Main Authors: Jang, Sung-Wuk, Liu, Xia, Yepes, Manuel, Shepherd, Kennie R., Miller, Gary W., Liu, Yang, Wilson, W. David, Xiao, Ge, Blanchi, Bruno, Sun, Yi E., Ye, Keqiang
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823863/
https://ncbi.nlm.nih.gov/pubmed/20133810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913572107
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