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Retroviral-mediated gene transfer and expression of human phenylalanine hydroxylase in primary mouse hepatocytes.

Genetic therapy for phenylketonuria (severe phenylalanine hydroxylase deficiency) may require introduction of a normal phenylalanine hydroxylase gene into hepatic cells of patients. We report development of a recombinant retrovirus based on the N2 vector for gene transfer and expression of human phe...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Peng, H, Armentano, D, MacKenzie-Graham, L, Shen, R F, Darlington, G, Ledley, F D, Woo, S L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282383/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3186716/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.21.8146
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