Retroviral-mediated gene transfer and expression of human phenylalanine hydroxylase in primary mouse hepatocytes.
Genetic therapy for phenylketonuria (severe phenylalanine hydroxylase deficiency) may require introduction of a normal phenylalanine hydroxylase gene into hepatic cells of patients. We report development of a recombinant retrovirus based on the N2 vector for gene transfer and expression of human phe...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1988
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3186716/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.21.8146 |
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