Signal peptides are allosteric activators of the protein translocase

Extra-cytoplasmic polypeptides are usually synthesized as “preproteins” carrying aminoterminal, cleavable signal peptides1 and secreted across membranes by translocases. The main bacterial translocase comprises the SecYEG protein-conducting channel and the peripheral ATPase motor SecA2,3. Most prote...

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Bibliographic Details
Main Authors: Gouridis, Giorgos, Karamanou, Spyridoula, Gelis, Ioannis, Kalodimos, Charalampos G., Economou, Anastassios
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823582/
https://ncbi.nlm.nih.gov/pubmed/19924216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08559
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