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Adipocyte-Mononuclear Cell Interaction, Toll-like Receptor 4 Activation, and High Glucose Synergistically Up-regulate Osteopontin Expression via an Interleukin 6-mediated Mechanism

Although it has been reported that osteopontin, a matrix glycoprotein and proinflammatory cytokine, mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance, it remains unclear how osteopontin is up-regulated in adipose tissue in obese humans and animals. In this study,...

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Bibliografiske detaljer
Main Authors: Samuvel, Devadoss J., Sundararaj, Kamala P., Li, Yanchun, Lopes-Virella, Maria F., Huang, Yan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823534/
https://ncbi.nlm.nih.gov/pubmed/20007708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.033951
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