Role of HuR and p38(MAPK) in Ultraviolet B-induced Post-transcriptional Regulation of COX-2 Expression in the Human Keratinocyte Cell Line HaCaT

COX-2 (cyclooxygenase-2) is a pivotal player in inflammatory processes, and ultraviolet radiation is a known stimulus for COX-2 expression in skin cells. Here, an induction of COX-2 expression in HaCaT human keratinocytes was observed only upon exposure of cells to UVB (280–320 nm) but not to UVA ra...

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Detalhes bibliográficos
Main Authors: Fernau, Niklas S., Fugmann, Dominik, Leyendecker, Martin, Reimann, Kerstin, Grether-Beck, Susanne, Galban, Stefanie, Ale-Agha, Niloofar, Krutmann, Jean, Klotz, Lars-Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823532/
https://ncbi.nlm.nih.gov/pubmed/19917608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.081430
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