Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes.

Incubation of fibroblasts derived from patients with type-C Niemann-Pick disease with low density lipoprotein results in excessive intracellular accumulation of unesterified cholesterol. Cytochemical techniques revealed that this abnormal cholesterol accumulation is associated not only with a massiv...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Blanchette-Mackie, E J, Dwyer, N K, Amende, L M, Kruth, H S, Butler, J D, Sokol, J, Comly, M E, Vanier, M T, August, J T, Brady, R O
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1988
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282346/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3186703/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.21.8022
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