Interleukin-21 can efficiently restore impaired antibody-dependent cell-mediated cytotoxicity in patients with oesophageal squamous cell carcinoma

BACKGROUND: We previously reported that Trastuzumab- and Cetuximab-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) in cancer patients was impaired in comparison with that in healthy donors because of NK-cell dysfunction. In this study, we evaluated whether IL-21 could improve the impai...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Watanabe, M, Kono, K, Kawaguchi, Y, Mizukami, Y, Mimura, K, Maruyama, T, Fujii, H
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2010
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822939/
https://ncbi.nlm.nih.gov/pubmed/20029417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605502
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