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Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

Eukaryotic pre-mRNA splicing is a complex process requiring the precise timing and action of >100 trans-acting factors. It has been known for some time that the two steps of splicing chemistry require three DEAH-box RNA helicase-like proteins; however, their mechanism of action at these steps has...

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Autors principals: Lardelli, Rea M., Thompson, James X., Yates, John R., Stevens, Scott W.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822917/
https://ncbi.nlm.nih.gov/pubmed/20089683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2030510
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