Noninvasive detection of target modulation following phosphatidylinositol-3-kinase inhibition using hyperpolarized (13)C magnetic resonance spectroscopy

Numerous mechanism-based anticancer drugs that target the phosphatidylinositol-3-kinase (PI3K) signaling pathway are in clinical trials. However, assessment of response using traditional imaging methods remains a challenge, as it is often associated with tumor stasis. Here we show for the first time...

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Detalhes bibliográficos
Main Authors: Ward, Christopher S., Venkatesh, Humsa S., Chaumeil, Myriam M., Brandes, Alissa H., VanCriekinge, Mark, Dafni, Hagit, Sukumar, Subramaniam, Nelson, Sarah J., Vigneron, Daniel B., Kurhanewicz, John, James, C. David, Haas-Kogan, Daphne A., Ronen, Sabrina M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822895/
https://ncbi.nlm.nih.gov/pubmed/20145128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2251
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