DOWNREGULATION OF RAP1GAP THROUGH EPIGENETIC SILENCING AND LOSS OF HETEROZYGOSITY PROMOTES INVASION AND PROGRESSION OF THYROID TUMORS

Thyroid cancer is the most common type of endocrine malignancy and encompasses tumors with various levels of invasive growth and aggressiveness. Rap1GAP, a Rap1 GTPase activating protein, inhibits a RAS family member Rap1 by facilitating hydrolysis of GTP to GDP. In this study, we analyzed 197 thyro...

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Main Authors:	Zuo, Hui, Gandhi, Manoj, Edreira, Martin M, Hochbaum, Daniel, Nimgaonkar, Vishwajit L, Zhang, Ping, DiPaola, James, Evdokimova, Viktoria, Altschuler, Daniel L, Nikiforov, Yuri E.
Format:	Artigo
Language:	Inglês
Published:	2010
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2822891/ https://ncbi.nlm.nih.gov/pubmed/20124489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2812
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DOWNREGULATION OF RAP1GAP THROUGH EPIGENETIC SILENCING AND LOSS OF HETEROZYGOSITY PROMOTES INVASION AND PROGRESSION OF THYROID TUMORS

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