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Low molecular weight (LMW) cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors
PURPOSE: Low-molecular-weight cyclin E (LMW-E) in breast cancer cells induces genomic instability, and resistance to inhibition by p21, p27, and fulvestrant therapy. Here, we sought to determine if LMW-E renders breast cancer cells unresponsive to aromatase inhibitors (AI), elucidate the mechanism o...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822889/ https://ncbi.nlm.nih.gov/pubmed/20145171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1787 |
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