Phase I Oncology Studies: Evidence That in the Era of Targeted Therapies, Patients on Lower Doses Do Not Fare Worse

PURPOSE: To safely assess new drugs, cancer patients in initial cohorts of phase I oncology studies receive low drug doses. Doses are successively increased until the maximum tolerated dose (MTD) is determined. Since traditional chemotherapy is often more effective near the MTD, ethical concerns hav...

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Bibliographic Details
Main Authors: Jain, Rajul K., Lee, J. Jack, Hong, David, Markman, Maurie, Gong, Jing, Naing, Aung, Wheler, Jennifer, Kurzrock, Razelle
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822881/
https://ncbi.nlm.nih.gov/pubmed/20145187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2684
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