Prolactin Inhibits Expression of the Proto-oncogene BCL6 in Breast Cancer through a Stat5a Dependent Mechanism

Stat5a mediates prolactin-induced differentiation of mammary epithelia, and loss of Stat5 signaling in human breast cancer is associated with undifferentiated histology and poor prognosis. The transcriptional repressor BCL6 shares DNA target sequences with Stat5, disrupts differentiation of breast e...

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Bibliographic Details
Main Authors:	Tran, Thai H., Utama, Fransiscus E., Lin, Justin, Yang, Ning, Sjolund, Ashley B., Ryder, Amy, Johnson, Kevin J., Neilson, Lynn M., Liu, Chengbao, Brill, Kristin L., Rosenberg, Anne L., Witkiewicz, Agnieszka K., Rui, Hallgeir
Format:	Artigo
Language:	Inglês
Published:	2010
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2822876/ https://ncbi.nlm.nih.gov/pubmed/20124477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2314
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Prolactin Inhibits Expression of the Proto-oncogene BCL6 in Breast Cancer through a Stat5a Dependent Mechanism

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