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Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor.

Analogs of interleukin 2 containing defined amino acid substitutions and deletions were assayed for bioactivity and for competitive binding to the high-affinity human interleukin 2 receptor complex and its two component subunits, a 55-kDa subunit (p55 or TAC) and a 70-kDa subunit (p70). Substitution...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Collins, L, Tsien, W H, Seals, C, Hakimi, J, Weber, D, Bailon, P, Hoskings, J, Greene, W C, Toome, V, Ju, G
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1988
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC282262/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3051003/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.20.7709
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