Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor.

Analogs of interleukin 2 containing defined amino acid substitutions and deletions were assayed for bioactivity and for competitive binding to the high-affinity human interleukin 2 receptor complex and its two component subunits, a 55-kDa subunit (p55 or TAC) and a 70-kDa subunit (p70). Substitution...

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Hauptverfasser: Collins, L, Tsien, W H, Seals, C, Hakimi, J, Weber, D, Bailon, P, Hoskings, J, Greene, W C, Toome, V, Ju, G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1988
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC282262/
https://ncbi.nlm.nih.gov/pubmed/3051003
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