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Differences in the transactivation domains of p53 family members: a computational study
The N terminal transactivation domain of p53 is regulated by ligases and coactivator proteins. The functional conformation of this region appears to be an alpha helix which is necessary for its appropriate interactions with several proteins including MDM2 and p300. Folding simulation studies have be...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822533/ https://ncbi.nlm.nih.gov/pubmed/20158876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-S1-S5 |
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