Elevated Ca(2+) sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

Ca(+) sparklets are subcellular Ca(2+) signals produced by the opening of L-type Ca(2+) channels (LTCCs). In cerebral arterial myocytes, Ca(2+) sparklet activity varies regionally, resulting in low and high activity, “persistent” Ca(2+) sparklet sites. Although increased Ca(2+) influx via LTCCs in a...

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Main Authors: Navedo, Manuel F., Takeda, Yukari, Nieves-Cintrón, Madeline, Molkentin, Jeffery D., Santana, Luis F.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2010
Teme:
Vascular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822492/
https://ncbi.nlm.nih.gov/pubmed/19846755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00267.2009
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